Glucagon-Like Peptide-1 Receptor
GLP1R is the cell-surface receptor that GLP-1 drugs like semaglutide and tirzepatide bind to. A common variant (rs10305420, Pro7Leu) changes how efficiently the receptor gets made and shipped to the cell surface. Leu7 carriers tend to lose a bit more weight on GLP-1 drugs, but they also get more nausea and vomiting.
Gene2Rx reports your GLP1R genotype across 2 named alleles, built from 1 variant curated by PharmVar.
GLP1R alleles are named by the underlying DNA variant rather than a star number — for example c.61C>T describes a single base change at position 61 of the coding sequence.
You inherit one allele from each parent, and the pair determines whether your GLP1R activity is normal, decreased, or absent.
PharmVar is the international registry that curates these names. Gene2Rx tests every variant needed to call each cataloged GLP1R allele.
Gene2Rx covers 3 medications with published pharmacogenetic guidance for GLP1R, drawn from CPIC and FDA sources. Each drug links to its full pharmacogenetics page.
These branded medications include at least one active ingredient whose metabolism or action involves GLP1R. Each links to its full pharmacogenetic breakdown.
This page lists drugs affected by GLP1R. A Gene2Rx report tells you which metabolizer group you fall into, and what that means for every medication on this list.
Get your report Look up a medicationInformational only, not medical advice. The presence of a GLP1R pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.