Cytochrome P450 4F2
CYP4F2 metabolizes vitamin K. A variant called V433M (rs2108622) reduces enzyme activity, so more vitamin K reaches the clotting cascade. Carriers therefore need slightly higher warfarin doses to achieve the same anticoagulant effect, on top of the much larger effects of CYP2C9 and VKORC1.
Gene2Rx reports your CYP4F2 genotype across 3 named star alleles, built from 2 variants curated by PharmVar.
Star alleles (like *1, *2, *4) are standardized names for distinct versions of a pharmacogene. *1 is the reference; higher numbers identify variants discovered later that change the enzyme's activity.
You inherit one allele from each parent, so your genotype is a pair (e.g. *1/*4). The pair determines your predicted phenotype — for example, whether you metabolize a drug at a normal, decreased, or no-function rate.
PharmVar is the international registry that defines and curates these allele names. Gene2Rx tests the variants required to call every CYP4F2 allele in the PharmVar catalog.
Gene2Rx covers 1 medication with published pharmacogenetic guidance for CYP4F2, drawn from CPIC and FDA sources. Each drug links to its full pharmacogenetics page.
These branded medications include at least one active ingredient whose metabolism or action involves CYP4F2. Each links to its full pharmacogenetic breakdown.
This page lists drugs affected by CYP4F2. A Gene2Rx report tells you which metabolizer group you fall into, and what that means for every medication on this list.
Get your report Look up a medicationInformational only, not medical advice. The presence of a CYP4F2 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.