ATP-Binding Cassette Subfamily G Member 2 (BCRP)
ABCG2 is a transporter that moves urate and several drugs out of cells. The Q141K variant (rs2231142) is common, particularly in East Asian populations, and reduces transporter function. Carriers have higher baseline serum urate and a smaller response to allopurinol, so they often need higher doses or a switch to a different urate-lowering drug. ABCG2 also affects how quickly the body clears rosuvastatin.
Gene2Rx reports your ABCG2 genotype across 2 named alleles, built from 1 variant curated by PharmVar.
ABCG2 alleles are named by the underlying DNA variant rather than a star number — for example c.61C>T describes a single base change at position 61 of the coding sequence.
You inherit one allele from each parent, and the pair determines whether your ABCG2 activity is normal, decreased, or absent.
PharmVar is the international registry that curates these names. Gene2Rx tests every variant needed to call each cataloged ABCG2 allele.
Gene2Rx covers 2 medications with published pharmacogenetic guidance for ABCG2, drawn from CPIC and FDA sources. Each drug links to its full pharmacogenetics page.
These branded medications include at least one active ingredient whose metabolism or action involves ABCG2. Each links to its full pharmacogenetic breakdown.
This page lists drugs affected by ABCG2. A Gene2Rx report tells you which metabolizer group you fall into, and what that means for every medication on this list.
Get your report Look up a medicationInformational only, not medical advice. The presence of a ABCG2 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.