Ondansetron, marketed under the brand name Zofran, is a medication commonly used to prevent and treat nausea and vomiting. It belongs to the class of 5-HT3 (serotonin) receptor antagonists and is widely prescribed in oncology, radiation therapy, and postoperative settings.
This drug is approved for managing chemotherapy- and radiation-induced nausea and vomiting, as well as postoperative nausea and vomiting. By blocking serotonin signals at 5-HT3 receptors in the central nervous system and gastrointestinal tract, ondansetron helps reduce the vomiting reflex.
Ondansetron is available in oral tablet, dissolvable film, and injectable forms, allowing flexibility based on patient needs and treatment settings.