Is Anectine affected by genetics?

Yes — the active ingredient is metabolized by a gene known to vary between individuals.

Relevant genes: BCHE

Anectine is affected by pharmacogenetics through the BCHE gene. Your genotype for this gene can change how your body processes Anectine, which can affect both how well it works and how well you tolerate it. The strongest evidence level on this page is Strong, based on CPIC or FDA guidelines.

What's in Anectine

succinylcholine affected by BCHE

Affected by BCHE · FDA · Strong evidence

Read the full succinylcholine genetics guide →

Succinylcholine phenotype recommendations

Published guidance from FDA on how succinylcholine should be dosed or substituted based on your BCHE phenotype.

Phenotype	What it means	Recommendation	Evidence
Intermediate Metabolizer BCHE	Your genetic result suggests you may process this anesthetic more slowly, which could increase the chance of prolonged muscle effects; your doctor may test your sensitivity and adjust the dosing carefully.	FDA May administer a test dose to assess sensitivity; if proceeding, administer cautiously via slow infusion with close monitoring.	Strong
Poor Metabolizer BCHE	Because your body processes this drug much more slowly, there’s a higher risk of long-lasting muscle effects; your doctor will likely use a different medication.	FDA Avoid use of succinylcholine; select alternative agents not affected by BCHE activity.	Strong
Normal Metabolizer BCHE	Your genetic result suggests you should process this medicine normally, but your doctor will manage dosing as usual.	FDA Initiate therapy with recommended starting dose and adjust per standard clinical practice.	Strong
Indeterminate BCHE	The impact of your genotype on response to this drug is unknown.	FDA Initiate therapy with recommended starting dose.	—
Not available BCHE	The impact of your genotype on response to this drug is unknown.	FDA Initiate therapy with recommended starting dose.	—

Source: FDA

Find out how your genetics affect Anectine

This page describes the general pharmacogenetics. A Gene2Rx report analyzes your own DNA to tell you which metabolizer group you fall into, across every medication.

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Informational only — not medical advice. Pharmacogenetic guidance describes population-level patterns; your individual response depends on many factors. Never start, stop, or change a medication without talking to your prescribing clinician.