Pharmacogenetics (PGx) helps explain why the same medication and dose can feel “right” for one person and ineffective or side effect prone for another. Genetics is not the only factor that matters, but it can influence how your body metabolizes medications and how likely you are to experience certain gene linked response differences.

Today, people can access PGx insights in a few different ways, and the best choice depends on what you need right now: a fast starting point, a clinically integrated lab test, or a test paired with a provider visit. Below is a practical, science-forward comparison to help you choose.

The landscape: two main paths to PGx insights

Most pharmacogenetic services fall into one of these categories:

1) Interpretation of existing direct-to-consumer DNA data
If you already have genotyping data from services like 23andMe, AncestryDNA, or MyHeritage, you can generate a PGx style report without collecting a new sample. Gene2Rx is designed for this workflow.

2) Clinical laboratory PGx testing (ordered or authorized by a clinician)
These services typically collect a cheek swab (or similar sample), run the test in a clinical lab, and deliver results through a clinician workflow. Examples include GeneSight, Genomind, and OneOme’s RightMed Test.

Both paths can be useful. The right choice depends on speed, cost, scope, and how tightly you want the result embedded into clinical care.

Gene2Rx at a glance: fast, affordable PGx insights from DNA you already have

Gene2Rx is built for people who already have consumer DNA data and want actionable pharmacogenetics insights quickly. You upload your genetic data and receive results in under 1 minute, with pricing starting at $15 and common report options in the $15 to $35 range depending on scope.

Gene2Rx reports cover 103 medications across multiple categories, not only mental health medications.

Head-to-head comparison: what differs most across services

1) Time to results: minutes vs days plus logistics

Gene2Rx
If you already have a compatible raw DNA file, Gene2Rx is optimized for speed: results are described as available in minutes and “under 1 minute after upload.”

GeneSight (Myriad Neuroscience)
GeneSight is a clinician ordered test. Their clinician FAQ notes results are typically available on the portal within 2 days after the lab receives the sample.
In practice, the total timeline can include scheduling, kit transit, and follow-up discussion with a clinician, which may or may not matter depending on your situation.

Genomind
Genomind’s direct-to-you option includes authorization from a licensed telehealth provider, shipment of a kit, and a virtual consultation. Genomind has also described lab turnaround times of under three days from sample receipt in certain offerings, with results delivered to the physician.

OneOme RightMed
RightMed is a provider ordered test that runs in OneOme’s CLIA certified, CAP accredited lab. OneOme has stated lab turnaround times of 4 to 5 days for certain programs.

Practical takeaway: If you already have consumer DNA data and your priority is speed, Gene2Rx is designed to be the fastest path from file to report. If you need a test embedded in a clinician workflow, lab-based services can be a better fit but typically require more steps.

2) Cost and transparency: low out-of-pocket vs insurance-style billing

Gene2Rx
Gene2Rx emphasizes transparent, direct pricing and lists pricing. For a complete Gene2Rx Pharmacogenetics Report, the price is $35, with treatment specific reports available at a discount (Psychiatric Medications: $25, Pain Medications: $15).

GeneSight
GeneSight’s insurance information describes an insurance billing process and a cost cap policy (the “GeneSight Promise”), where they state they will contact patients if the cost is determined to exceed $330 before processing.

OneOme RightMed
OneOme describes a self-pay option of $349 and a financial assistance pathway with a maximum out-of-pocket cost of $199 for qualifying patients.

Genomind
Genomind describes a “low, one-time fee” for its at-home PGx test paired with telehealth and counseling, though the exact price may vary by offering and is not always shown directly on the overview page.

Practical takeaway: If minimizing upfront cost is the main goal, Gene2Rx is positioned as a low-cost onramp for PGx insights.

3) Access: no clinician required vs clinician ordered testing

Gene2Rx
Gene2Rx is direct-to-consumer and does not require a prescription or healthcare provider authorization to generate a report from supported consumer DNA data.

GeneSight
GeneSight explicitly states the test must be ordered by a registered clinician.

OneOme RightMed
OneOme states the RightMed test must be ordered by a licensed healthcare provider.

Genomind
Genomind’s at-home PGx pathway includes authorization from a licensed telehealth provider and a clinician review of results.

4) Scope: broad medication coverage vs targeted panels

Gene2Rx
Gene2Rx covers 103 medications, spanning multiple drug classes (not only psychiatric medications).

GeneSight
GeneSight describes its primary offering as focused on medications prescribed for depression, anxiety, ADHD, and other psychiatric conditions, with the psychotropic test including over 60 medications. (Genesight FAQ)

OneOme RightMed
OneOme describes its report outputs as classifying “100+ medications” according to a patient’s genotypes in its comprehensive report offering. (OneOme Report)

Practical takeaway: If you are specifically looking for psychiatric medication decision support inside a clinician workflow, services like GeneSight or Genomind may align well. If you want broader categories covered quickly from existing consumer DNA data, Gene2Rx is built for that use case.

Evidence standards: where the guidance comes from

Gene2Rx uses the latest peer-reviewed PGx guidance and points to CPIC and FDA as key sources of evidence-based recommendations. GeneSight also references integrating FDA labels and published clinical studies into its reporting approach. However, many services provide custom interpretation of genetic implications that are not always transparent.

This matters because PGx evidence quality varies widely by drug-gene pair. Not every medication has strong PGx guidance, and not every gene variant has the same clinical relevance.

A note on “clinical grade”: important, but not the whole story

It’s worth stating clearly and calmly:

In contrast, clinician ordered services like GeneSight and OneOme describe testing performed in CLIA certified and CAP accredited laboratories, aligning with clinical laboratory quality systems.

How to interpret this in real life: Gene2Rx can be an excellent rapid starting point for learning and for generating questions to bring to a clinician. If you are making high-stakes medication decisions or need results used directly in clinical prescribing workflows, a clinician ordered clinical lab test may be more appropriate.

Choosing the right option: a quick decision guide

Choose Gene2Rx if: - You already have 23andMe, AncestryDNA, or MyHeritage data and want results fast.
- You want low, transparent pricing and a quick way to prioritize what to discuss with your clinician. - You are looking for broader medication categories beyond psychiatric only.

Consider clinician ordered testing (GeneSight, Genomind, OneOme RightMed) if: - You want a test designed to be used directly inside a clinical care plan and ordering workflow. - You prefer a clinical lab sample and a report routed through a provider portal, often with clinical consult support. - You are comfortable with the additional time, steps, and potential insurance-style billing process.

Bottom line

Gene2Rx is designed to make pharmacogenetics accessible for people who already have consumer DNA data, with a focus on speed (under 1 minute after upload) and affordability (starting at $15). Clinical services like GeneSight, Genomind, and OneOme RightMed play an important role when you need clinician ordered testing, lab-based workflows, and integration into medical decision-making.

Regardless of which option you choose, PGx results are most useful when discussed with a qualified healthcare professional.