DISCLAIMER

DO NOT ALTER YOUR MEDICATION OR DOSAGE OR STOP YOUR MEDICATION WITHOUT FIRST CONSULTING YOUR HEALTHCARE PROVIDER.

Direct-to-consumer data is not clinical grade, so anything included in the report should be used only as a conversation starter with your healthcare provider to seek the appropriate clinical laboratory test. Again, do not alter your medication dosage or stop taking your medication without first consulting your healthcare provider.

• What medications are included in my report?

  Gene2Rx analyzes your DNA and detects genetic variations that may lead to an atypical response to 79 medications, including antidepressants, pain medication, statins, among others. Each drug has guidance provided by the Food and Drug Administration or the Clinical Pharmacogenomics Implementation Consortium (CPIC). See here for a full list of analyzed medications.

• Should I change medications or dosage based on my report?

  No! Do not alter your medication dosage or stop taking your medication without first consulting your healthcare provider. Direct-to-consumer data is not clinical grade, so anything included in the report should be used as a conversation starter with your healthcare provider to seek the appropriate clinical laboratory test. Again, do not alter your medication dosage or stop taking your medication without first consulting your healthcare provider.

• Why shouldn't I change my medication based on this report?

  Our service relies on the genetic information provided to you by the direct-to-consumer service you paid for. Unfortunately, direct-to-consumer data is not clinical grade, so anything included in the report should be used as a conversation starter with your healthcare provider to seek the appropriate clinical laboratory test. DO NOT alter your medication dosage or stop taking your medication without first consulting your healthcare provider. Read more here and read primary research here.

• Are these expert annotations?

  Yes. For each drug included in the report either the FDA, CPIC, or both have deemed the evidence of a drug-gene interaction sufficient to provide clinical prescription guidance based on an individuals genetics. The Clinical Pharmacogenetics Implementation Consortium (CPIC) is a group of PGx experts that volunteer their time to curate genetic guidance for drug response, based on the most recent research. They have high standards for the evidence required to include a drug-gene guideline. You can read more about this organization on their website.

• Do you recommend a particular DTC service?

  We currently recommend 23andMe over AncestryDNA and MyHeritage, as 23andMe directly meaures more of the genetic data that matters for identifying gene-drug relationships. Additionally, based on internal validation metrics, our annotations tend to be most accurate when using 23andMe data.

• Why would my PGx annotations change?

  While your genetics don't change over the course of your life, research is an ongoing process and what we know about how an individual's genetics influences their drug response changes over time. As new research is conducted and published, the CPIC guidelines are updated accordingly. These updates only happen once new research meets strict validation requirements and experts agree its time for a guideline change. If you buy a one-time report, we'll provide the CPIC guidance at that point in time.

• How do I get my genotype data?

  We currently support data generated by 23andMe, AncestryDNA, and MyHeritage. If you have data from another service and would like to use Gene2Rx please contact us using the form below and we can may be able to assist you.

  Use the links below to your DNA provider to download your raw data.

  23andme data download instructions
  AncestryDNA data download instructions
  MyHeritageDNA data download instructions

• Do you have an example report?

  Yes! Check out example reports to see if Gene2Rx is right for you.